Oncogenic Osteomalacia: An Approach to Diagnosis with a Case Report
Published: April 1, 2017 | DOI: https://doi.org/10.7860/JCDR/2017/25055.9634
Biswajit Dey, Debasis Gochhait, Hema Subramanian, Madhusudhanan Ponnusamy
1. Senior Resident, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
2. Assistant Professor, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
3. Junior Resident, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
4. Assistant Professor, Department of Nuclear Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
Correspondence
Dr. Debasis Gochhait, Assistant Professor,
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER),
Puducherry-605006, India.
E-mail: publicationmail@rediffmail.com
Oncogenic osteomalacia, also known as tumour induced osteomalacia, is a rare paraneoplastic syndrome caused by mesenchymal tumours secreting Fibroblast Growth Factor-23 (FGF-23). The characteristic biochemical findings include hypophosphatemia and low 1,25-dihydroxy vitamin D. The differential diagnosis for hypophosphatemia are varied. We present a case of oncogenic osteomalacia in a 29-year-old female, who presented with complaints of generalized diffuse bone pain and walking difficulty for six months duration. Thus, we have discussed the approach to diagnosis in such a case.
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